1. Liver Fact Sheet 2020. World Health Organization. Available at Accessed 23 Feb 2021.
  2. China Fact Sheet 2020. World Health Organization. Available at Accessed 23 Feb 2021.
  3. Liver Cancer Risk Factors. American Cancer Society. Available at Accessed 14 Jan 2021.
  4. Up to 10 million people in China could die from chronic hepatitis by 2030 – Urgent action needed to bring an end to the ‘silent epidemic’. World Health Organization. 2016. Available at Accessed 14 Jan 2021.
  5. Hong Kong Viral Hepatitis Action Plan 2020 – 2024. Hospital Authority. Available at Accessed 23 Feb 2021.
  6. Leading Cancer Sites in Hong Kong in 2019. Hong Kong Cancer Registry. Hospital Authority. Available at Accessed 13 July 2022.
  7. Li D, Sedano S, Allen R, Gong J, Cho M, Sharma S. Current treatment landscape for advanced hepatocellular carcinoma: patient outcomes and the impact on quality of life. Cancers. 2019;11:841.
  8. Kudo M, Finn R, Qin S, et al. Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. Lancet. 2018;391:1163–1173.
  9. FDA approves atezolizumab plus bevacizumab for unresectable hepatocellular carcinoma. U.S. Food and Drug Administration. Available at Accessed 27 July 2022.
  10. Summary of opinion: Tecentriq. European Medicines Agency. Available at Accessed 27 July 2022.
  11. TECENTRIQ HK Prescribing Information. Roche.
  12. AVASTIN ROCHE HK Prescribing Information. Roche.
  13. Patient-Reported Outcomes From IMbrave150: Better Quality of Life With Doublet. The ASCO Post. Available at,in%20the%20pivotal%20IMbrave150%20trial. Accessed 25 Jan 2021.
  14. Cancer Expert Working Group on Cancer Prevention and Screening 2016 Recommendations on Prevention and Screening for Liver Cancer For Health Professionals. Available at Accessed 4th May 2021.
  15. El-Serag HB et al. Surveillance for hepatocellular carcinoma: in whom and how? Ther Adv Gastroenterol 2011; 4: 5–10.
  16. Marrero JA, Kulik LM, Sirlin CB, et al. Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology. 2018;68(2):723-750. doi:10.1002/hep.29913
  17. Wang CS, Lin CL, Lee HC, et al. Usefulness of serum des-gamma-carboxy prothrombin in detection of hepatocellular carcinoma. World J Gastroenterol. 2005;11(39):6115-6119. doi:10.3748/wjg.v11.i39.6115
  18. EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma., Journal of Hepatology, Volume 69, Issue 1, 2018, Pages 182-236, ISSN 0168-8278; Sherman M. Limitations of screening for hepatocellular carcinoma. Hepat Oncol. 2014;1(2):161–163. doi:10.2217/hep.13.22.
  19. Chan, H. L. Y., et al. (2020). Elecsys PIVKA-II and elecsys AFP assays demonstrate good clinical performance for Hepatocellular Carcinoma (HCC) diagnosis across different disease stages and etiologies. In The Liver Meeting Digital Experience™. AASLD.
  20. Sheu JC et al. Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications. Gastroenterology 1985; 89: 259–266.
  21. Kao WY et al. Prognosis of Early-Stage Hepatocellular Carcinoma: The Clinical Implications of Substages of Barcelona Clinic Liver Cancer System Based on a Cohort of 1265 Patients. Medicine 2015; 94(43): e1929
  22. Sastre J et al. Clinical guideline SEOM: hepatocellular carcinoma. Clin Transl Oncol 2015; 17: 988–995
  23. Singal A et al. Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis. Aliment Pharmacol Ther 2009; 30: 37–47
  24. Liver Cancer. Cancer Fund. Available at Accessed 13 July 2022.
  25. 患上肝癌,怎麼辦:肝癌治療方法簡介. 香港中文大學肝臟護理中心. Available at Accessed 13 July 2022.
  26. Treatment. Hong Kong Liver Cancer And Gastrointestinal Cancer Foundation. Available at Accessed 14 Jan 2022.
  27. Liver Cancer. The Hong Kong Anti-cancer Society. Available at Accessed 14 Jan 2022.
  28. How Targeted Therapies Are Used to Treat Cancer. American Cancer Society. Available at,that%20have%20already%20been%20made. Accessed 13 July 2022.
  29. What is Targeted Therapy. Available at,growth%2C%20like%20blood%20vessel%20cells. Accessed 13 July 2022.
  30. Why Immunotherapy? A Targeted Answer To Cancer. Cancer Research Institute. Available at Accessed 13 July 2022.